LAT and LCK

  • Number of citations of the paper that reports this interaction (PubMedID 12359715)
  • 30
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo, in vitro)

LAT

LCK

Description linker for activation of T cells LCK proto-oncogene, Src family tyrosine kinase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Allergic disease (asthma, hay fever or eczema) ( 29679657)
  • Crohn's disease ( 21102463)
  • Educational attainment ( 25201988)
Interacting Genes 33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2 128 interacting genes: ACP1 ADAM15 AJUBA ARHGAP17 AXL BCAR1 BRCA1 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CSF2RB CSF3R CSK CSNK2B CTLA4 CTNND1 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MS4A1 MUC1 NEDD9 NFKBIA NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRPV4 TUB UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70
Entrez ID 27040 3932
HPRD ID 03832 01080
Ensembl ID ENSG00000213658 ENSG00000182866
Uniprot IDs A0A024QZD6 O43561 A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4
PDB IDs 1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?