SH3BP2 and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 17306257)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		SH3BP2	SH3KBP1
Description		SH3 domain binding protein 2	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding	Protein Binding SH3 Domain Binding
	Biological Process	Signal Transduction Positive Regulation Of Signal Transduction	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Cherubism
GWAS		Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		24 interacting genes: ABL1 ARHGAP10 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		6452	30011
HPRD ID		03657	02301
Ensembl ID		ENSG00000087266	ENSG00000147010
Uniprot IDs		A0A384N6E5 P78314	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2CR4 3TWR	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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