LAT and CD244

Number of citations of the paper that reports this interaction (PubMedID 12077228)
9

Data Source:
HPRD (in vivo)

		LAT	CD244
Description		linker for activation of T cells	CD244 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Signal Transduction Innate Immune Response Leukocyte Migration Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Interacting Genes		33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	5 interacting genes: ARHGEF7 CD247 CD48 LAT SH2D1B
Entrez ID		27040	51744
HPRD ID		03832	16121
Ensembl ID		ENSG00000213658	ENSG00000122223
Uniprot IDs		A0A024QZD6 O43561	Q9BZW8
PDB IDs
Enriched GO Terms of Interacting Partners?
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