LAT and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 11279207)
13

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		LAT	MAP4K1
Description		linker for activation of T cells	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Cytoplasm Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		27040	11184
HPRD ID		03832	03583
Ensembl ID		ENSG00000213658	ENSG00000104814
Uniprot IDs		A0A024QZD6 O43561	Q92918
PDB IDs			6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0
Enriched GO Terms of Interacting Partners?
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