METTL21A and ATRIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		METTL21A	ATRIP
Description		methyltransferase like 21A	ATR interacting protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Protein-containing Complex	Nucleoplasm
	Molecular Function	Protein Binding Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Methylation Peptidyl-lysine Methylation Regulation Of ATPase Activity	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Protein methylation	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: ATRIP GIGYF2 HSPA1A HSPA5 HSPA8 LNX1 ZBED8	21 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2
Entrez ID		151194	84126
HPRD ID		14090
Ensembl ID		ENSG00000144401	ENSG00000164053
Uniprot IDs		C9JES0 H7BXH9 Q8WXB1	A0A024R2U4 A0A024R307 Q8WXE1
PDB IDs		4LEC	4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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