CLNK and LCP2

Number of citations of the paper that reports this interaction (PubMedID 10562326)
14

Data Source:
HPRD (in vitro)

		CLNK	LCP2
Description		cytokine dependent hematopoietic cell linker	lymphocyte cytosolic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways			GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		116449	3937
HPRD ID		14720	03362
Ensembl ID		ENSG00000109684	ENSG00000043462
Uniprot IDs		Q7Z7G1	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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