LCP2 and TRAT1

Number of citations of the paper that reports this interaction (PubMedID 10790433)
141

Data Source:
BioGRID (pull down)

		LCP2	TRAT1
Description		lymphocyte cytosolic protein 2	T cell receptor associated transmembrane adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway	Negative Regulation Of Receptor Recycling Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	11 interacting genes: CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SRC TRA TRB
Entrez ID		3937	50852
HPRD ID		03362	05392
Ensembl ID		ENSG00000043462	ENSG00000163519
Uniprot IDs		Q13094	C9JF66 Q6PIZ9
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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