CLNK and WWOX

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		CLNK	WWOX
Description		cytokine dependent hematopoietic cell linker	WW domain containing oxidoreductase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein-containing Complex Binding	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	25 interacting genes: APBB2 CLNK CPSF2 CPSF7 ERBB4 EZR FIP1L1 HNRNPK HYAL2 LATS1 MAPK8 NUDT21 SCAMP3 SEC23IP SF3B3 SMAD4 SRC TCERG1 TFAP2C TNK2 TP53 TP73 UBB WDR33 WIPF2
Entrez ID		116449	51741
HPRD ID		14720	05501
Ensembl ID		ENSG00000109684	ENSG00000186153
Uniprot IDs		Q7Z7G1	A0A411HBC7 Q9NZC7
PDB IDs			1WMV
Enriched GO Terms of Interacting Partners?
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