LCP2 and TXK

Number of citations of the paper that reports this interaction (PubMedID 8702662)
85

Data Source:
HPRD (in vitro, in vivo)

		LCP2	TXK
Description		lymphocyte cytosolic protein 2	TXK tyrosine kinase
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GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway	Cytokine Production Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252)
Interacting Genes		43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	11 interacting genes: CCR5 CLNK CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1
Entrez ID		3937	7294
HPRD ID		03362	02505
Ensembl ID		ENSG00000043462	ENSG00000074966
Uniprot IDs		Q13094	P42681
PDB IDs		1H3H 1YWO 2EAP 2ROR	2DM0
Enriched GO Terms of Interacting Partners?
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