CLNK and TXK

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		CLNK	TXK
Description		cytokine dependent hematopoietic cell linker	TXK tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein-containing Complex Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction	Cytokine Production Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways			FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252)
Interacting Genes		30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	11 interacting genes: CCR5 CLNK CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1
Entrez ID		116449	7294
HPRD ID		14720	02505
Ensembl ID		ENSG00000109684	ENSG00000074966
Uniprot IDs		Q7Z7G1	P42681
PDB IDs			2DM0
Enriched GO Terms of Interacting Partners?
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