LCP2 and PRAM1

Number of citations of the paper that reports this interaction (PubMedID 11301322)
12

Data Source:
HPRD (in vivo, in vitro)

		LCP2	PRAM1
Description		lymphocyte cytosolic protein 2	PML-RARA regulated adaptor molecule 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Protein Kinase Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Coronary artery disease ( 29212778) Height ( 18391951)
Interacting Genes		43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	19 interacting genes: A2M ABI2 APOE APP CCDC57 CDC37 FXR2 KRT40 LCP2 LYN MAST1 MXD1 NEK6 PSEN1 RNF32 SKAP1 SKAP2 TRIM27 UBE2E2
Entrez ID		3937	84106
HPRD ID		03362	05926
Ensembl ID		ENSG00000043462	ENSG00000133246
Uniprot IDs		Q13094	Q96QH2
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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