DTX2 and MDC1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid)

		DTX2	MDC1
Description		deltex E3 ubiquitin ligase 2	mediator of DNA damage checkpoint 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Membrane	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		44 interacting genes: ABHD16A ALKBH4 ARNT2 C1orf94 COQ8A DTX1 DTX3 EIF4ENIF1 FAM168A FHL2 GLYCTK GOLGA2 HDC HPCAL1 HPCAL4 KLC3 KRTAP26-1 MDC1 NCALD NCS1 NOTCH1 PLEKHF2 PLSCR1 QARS1 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 SEC22A SEC23B SPAG8 SPG21 STX12 SUMO1 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D3 UBE2D4 UBQLN4 VSNL1 ZNF641	39 interacting genes: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		113878	9656
HPRD ID		16841	16252
Ensembl ID		ENSG00000091073	ENSG00000137337
Uniprot IDs		Q86UW9	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		6IR0	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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