DTX2 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DTX2	NCS1
Description		deltex E3 ubiquitin ligase 2	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs			Calcium Citrate Calcium Phosphate
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		44 interacting genes: ABHD16A ALKBH4 ARNT2 C1orf94 COQ8A DTX1 DTX3 EIF4ENIF1 FAM168A FHL2 GLYCTK GOLGA2 HDC HPCAL1 HPCAL4 KLC3 KRTAP26-1 MDC1 NCALD NCS1 NOTCH1 PLEKHF2 PLSCR1 QARS1 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 SEC22A SEC23B SPAG8 SPG21 STX12 SUMO1 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D3 UBE2D4 UBQLN4 VSNL1 ZNF641	10 interacting genes: DRD2 DRD3 DRD5 DTX2 EXOSC2 GRK2 IL1RAPL1 KCND2 NBL1 PI4KB
Entrez ID		113878	23413
HPRD ID		16841	04500
Ensembl ID		ENSG00000091073	ENSG00000107130
Uniprot IDs		Q86UW9	A0A024R8B2 P62166
PDB IDs		6IR0	1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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