TOPBP1 and ABL1

Number of citations of the paper that reports this interaction (PubMedID 15961388)
7

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TOPBP1	ABL1
Description		DNA topoisomerase II binding protein 1	ABL proto-oncogene 1, non-receptor tyrosine kinase
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Nuclear Body Dendrite Cell Leading Edge Nuclear Membrane Protein-containing Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	Magnesium Ion Binding Four-way Junction DNA Binding Bubble DNA Binding Phosphotyrosine Residue Binding DNA Binding Transcription Coactivator Activity Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding Kinase Activity SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Neuropilin Binding SH2 Domain Binding Ephrin Receptor Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding Supercoiled DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator	Mitotic Cell Cycle Neural Tube Closure B-1 B Cell Homeostasis Positive Regulation Of Protein Phosphorylation B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Protein Phosphorylation Endocytosis Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Regulation Of Axon Extension Regulation Of Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Platelet-derived Growth Factor Receptor-beta Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Endothelial Cell Migration Establishment Of Protein Localization Regulation Of T Cell Differentiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Protein Autophosphorylation Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly Mitochondrial Depolarization Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Neuroepithelial Cell Differentiation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade DNA Conformation Change Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Cardiovascular System Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Actin Filament Branching Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Microtubule Binding Positive Regulation Of Actin Filament Binding Regulation Of Modification Of Synaptic Structure Positive Regulation Blood Vessel Branching Activation Of Protein Kinase C Activity Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs			ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Brigatinib Radotinib
Diseases			Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Iron status biomarkers ( 19084217)	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Response to amphetamines ( 22952603)
Interacting Genes		32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	158 interacting genes: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANAPC15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1A CDKN1B CDON CREB1 CRK CRKL CTNND2 DAPK1 DDB1 DDB2 DENND2B DOK1 DOK2 DOK3 DVL2 EMD ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL FBXO7 GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HIPK2 HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 LRRK1 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PDGFRB PIK3R1 PLCG1 PLEKHA4 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD51B RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHB SHD SHE SLC9A2 SOCS3 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRCIN1 SRPK2 STUB1 TERT TMPO TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16
Entrez ID		11073	25
HPRD ID		09678	01809
Ensembl ID		ENSG00000163781	ENSG00000097007
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	A0A024R8E2 P00519 Q59FK4
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM	1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 4ZOG 5DC0 5DC4 5DC9 5HU9 5MO4 5NP2 5OAZ 6AMV 6AMW 6BL8 6NPE 6NPU 6NPV
Enriched GO Terms of Interacting Partners?
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