TOPBP1 and GINS1

Number of citations of the paper that reports this interaction (PubMedID 23629628)
14

Data Source:
BioGRID (two hybrid)

		TOPBP1	GINS1
Description		DNA topoisomerase II binding protein 1	GINS complex subunit 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	GINS Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator	Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Involved In Mitotic DNA Replication
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Liver enzyme levels (alkaline phosphatase) ( 22001757) Telomere length ( 30185882)
Interacting Genes		32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	2 interacting genes: GINS4 TOPBP1
Entrez ID		11073	9837
HPRD ID		09678	11067
Ensembl ID		ENSG00000163781	ENSG00000101003
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q14691
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM	2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?
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