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ABL1 and YAP1
Number of citations of the paper that reports this interaction (PubMedID
18280240
)
116
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
HPRD
(in vitro, in vivo)
ABL1
YAP1
Description
ABL proto-oncogene 1, non-receptor tyrosine kinase
Yes1 associated transcriptional regulator
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
TEAD-1-YAP Complex
TEAD-2-YAP Complex
Molecular Function
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Activating Transcription Factor Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Proline-rich Region Binding
Biological Process
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Cardiovascular System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Interleukin-2 Secretion
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Interferon-gamma Secretion
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Cell Morphogenesis
Vasculogenesis
Tissue Homeostasis
Heart Process
Embryonic Heart Tube Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Cell Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Notochord Development
Response To Progesterone
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Hippo Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Lateral Mesoderm Development
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Progesterone Receptor Signaling Pathway
Positive Regulation Of Cardiac Muscle Cell Proliferation
Contact Inhibition
Bud Elongation Involved In Lung Branching
Lung Epithelial Cell Differentiation
Cardiac Muscle Tissue Regeneration
Protein-containing Complex Assembly
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Brigatinib
Radotinib
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Response to amphetamines (
22952603
)
Cleft palate (
27018472
)
Colorectal cancer or advanced adenoma (
30510241
)
Heel bone mineral density (
30598549
)
Migraine (
27322543
)
Offspring birth weight (
31043758
)
Polycystic ovary syndrome (
22885925
30566500
26416764
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Pulse pressure (
30224653
30578418
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
158 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
33 interacting genes:
ABL1
AKT1
ENAH
ERBB4
HNRNPU
KIF5A
LATS2
LINC00839
NFE2
OTUD1
PRRG2
PTCH1
PTEN
PTPN21
RUNX1
RUNX2
RUNX3
SCAMP3
SLC9A3R1
SMAD1
SMAD7
SUMO3
TEAD1
TEAD2
TEAD3
TEAD4
TP53BP2
TP73
WBP1
WBP2
YWHAG
YWHAQ
YWHAZ
Entrez ID
25
10413
HPRD ID
01809
09424
Ensembl ID
ENSG00000097007
ENSG00000137693
Uniprot IDs
A0A024R8E2
P00519
Q59FK4
A0A024R3E4
K0KVU2
P46937
Q86T74
PDB IDs
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
4RE1
4REX
5OAQ
5YDX
5YDY
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GE3
6GE4
6GE5
6GE6
6GEC
6GEE
6GEG
6GEI
6GEK
6HIK
6HIL
6Q2X
Enriched GO Terms of Interacting Partners
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