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ABL1 and RAD51
Number of citations of the paper that reports this interaction (PubMedID
10212258
)
65
Data Source:
BioGRID
(pull down, pull down)
HPRD
(in vitro, in vivo)
ABL1
RAD51
Description
ABL proto-oncogene 1, non-receptor tyrosine kinase
RAD51 recombinase
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Nuclear Chromosome
Nuclear Chromosome, Telomeric Region
Chromatin
Nuclear Chromatin
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Microtubule Organizing Center
PML Body
Protein-containing Complex
Site Of Double-strand Break
Perinuclear Region Of Cytoplasm
Molecular Function
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Recombinase Activity
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity
Enzyme Binding
Identical Protein Binding
DNA Polymerase Binding
Biological Process
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Cardiovascular System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Interleukin-2 Secretion
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Interferon-gamma Secretion
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
Regulation Of Protein Phosphorylation
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Mitotic Recombination
Cellular Response To DNA Damage Stimulus
Reciprocal Meiotic Recombination
Response To X-ray
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Replication Fork Processing
Interstrand Cross-link Repair
Strand Invasion
Positive Regulation Of DNA Ligation
Meiotic Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Negative Regulation Of G0 To G1 Transition
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Cellular Response To Cisplatin
Cellular Response To Camptothecin
Response To Glucoside
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Mitotic Recombination-dependent Replication Fork Processing
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Transcriptional Regulation by E2F6
Meiotic recombination
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Brigatinib
Radotinib
Phosphoaminophosphonic Acid-Adenylate Ester
Amuvatinib
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Response to amphetamines (
22952603
)
Anxiety and stress-related disorders (
31116379
)
Interacting Genes
158 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
93 interacting genes:
-
ABL1
AGO2
ATM
ATRX
BARD1
BCCIP
BCR
BLM
BRCA1
BRCA2
C1orf112
CASP3
CASP7
CCND1
CDH13
CHD3
CHEK1
CSNK2A1
CSNK2B
CST6
CTCF
DMC1
DNAJA3
ENAH
EP400
ERCC2
ERCC5
EVL
FANCD2
FANCI
FBH1
FIGNL1
HID1
HNRNPC
HSP90AA1
IL24
IRS1
ITIH5
MAPK8IP3
MDC1
MMS22L
MND1
MSH4
NBN
NCL
NELFB
NXF1
PALB2
PARPBP
PCSK1N
PDS5B
PFN1
PLK1
POLA1
RAD18
RAD51AP1
RAD51AP2
RAD51B
RAD51C
RAD52
RAD54B
RAD54L
RECQL5
RELA
RFWD3
RPA1
RPA2
RPA3
SEM1
SFR1
SIRT2
ST14
SUMO1
SUMO2
SWSAP1
TFF1
TP53
TP53BP1
UBE2I
UCHL3
UGDH
UHRF2
UMPS
USP10
VASP
VIM
WDR48
WRN
XPO1
XRCC2
XRCC3
ZDHHC17
Entrez ID
25
5888
HPRD ID
01809
01557
Ensembl ID
ENSG00000097007
ENSG00000051180
Uniprot IDs
A0A024R8E2
P00519
Q59FK4
Q06609
PDB IDs
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
1B22
1N0W
5H1B
5H1C
5JZC
5NP7
5NWL
Enriched GO Terms of Interacting Partners
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