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ABL1 and GRB2
Number of citations of the paper that reports this interaction (PubMedID
8194526
)
108
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vitro, two hybrid)
ABL1
GRB2
Description
ABL proto-oncogene 1, non-receptor tyrosine kinase
growth factor receptor bound protein 2
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Vesicle Membrane
Extracellular Exosome
Grb2-EGFR Complex
Molecular Function
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Phosphotyrosine Residue Binding
RNA Binding
SH3/SH2 Adaptor Activity
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Identical Protein Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Biological Process
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Cardiovascular System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Interleukin-2 Secretion
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Interferon-gamma Secretion
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Cell-cell Signaling
Axon Guidance
Aging
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Receptor Internalization
Entry Of Bacterium Into Host Cell
Interleukin-15-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Positive Regulation Of Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Leukocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Branching Involved In Labyrinthine Layer Morphogenesis
Membrane Organization
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Interleukin-15 signaling
Interleukin-15 signaling
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Brigatinib
Radotinib
Pegademase bovine
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Response to amphetamines (
22952603
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
29848360
26502338
28714469
)
Systemic sclerosis (
31672989
)
Interacting Genes
158 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
367 interacting genes:
A2M
ABI3
ABI3BP
ABL1
ABL2
ACAP1
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANXA2
AP4S1
APCS
APOH
APP
ARHGAP17
ARHGAP32
ARHGAP35
ARHGAP9
ASAP1
ASAP2
AUNIP
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CFH
CHRM4
CHRND
CKS2
CLNK
CLU
COPB1
COX6A1
CRBN
CRK
CRKL
CSF1R
CSF3R
CSN2
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
DVL2
E2F2
ECHS1
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESD
ESR1
ETV6
FABP1
FASLG
FCGR2A
FCGR2B
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GAREM1
GC
GHR
GIT1
GPANK1
GRAP2
GRB7
GSTK1
H1-0
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HSPA5
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA1549L
KIF3A
KIT
KPNA2
KPRP
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LNX2
LY6G6F
LZTS2
MAP1A
MAP2
MAP4K1
MAP4K3
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MAPT
MED28
MERTK
MET
METTL27
MIA2
MICAL1
MLXIPL
MS4A2
MSI2
MST1R
MT-ATP8
MT-ND4
MTA1
MTA3
MUC1
MYH11
MYH9
MYO18A
MYOZ1
NADK
NAP1L5
NCKIPSD
NCL
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
OLIG1
PACRGL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PCDHB5
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PLCG1
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRRC2A
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RPS6KA1
SELL
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TCEAL8
TCERG1
TEK
TF
TFG
TLE5
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIM27
TSC2
TSPAN2
TUB
UBA1
UBA52
UBC
UQCC2
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
WAS
WASF1
WASF2
WASL
WBP11
WDFY3
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB7B
ZMAT1
Entrez ID
25
2885
HPRD ID
01809
00150
Ensembl ID
ENSG00000097007
ENSG00000177885
Uniprot IDs
A0A024R8E2
P00519
Q59FK4
B0LPF3
P62993
PDB IDs
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
3WA4
4P9V
4P9Z
5CDW
6ICG
6ICH
Enriched GO Terms of Interacting Partners
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