NFE2 and PRIM1

		NFE2	PRIM1
Description		nuclear factor, erythroid 2	DNA primase subunit 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding	Single-stranded DNA Binding DNA Primase Activity Protein Binding Metal Ion Binding
	Biological Process	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Blood Circulation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Chronotype ( 30696823) Mean platelet volume ( 22139419 24026423) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 31619474) Height ( 31562340) Mean corpuscular volume ( 27863252) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 27863252) Red blood cell count ( 29403010)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1	14 interacting genes: MDC1 MRPL38 NFE2 PDE1B PRIM2 RAB5B RARG RPS26 SENP1 SLC11A2 SLC26A8 STAT6 TP53 YIF1A
Entrez ID		4778	5557
HPRD ID		09030	08899
Ensembl ID		ENSG00000123405	ENSG00000198056
Uniprot IDs		A8K3E0 Q16621	P49642
PDB IDs		1LVX 2KZ5	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4
Enriched GO Terms of Interacting Partners?
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