NDUFAF3 and NDUFAF4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		NDUFAF3	NDUFAF4
Description		NADH:ubiquinone oxidoreductase complex assembly factor 3	NADH:ubiquinone oxidoreductase complex assembly factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Binding Calmodulin Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Complex I biogenesis	Complex I biogenesis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: GEM KRTAP10-3 LSM1 NDUFAF4 RBCK1 REL SCAP SNRPA	1 interacting genes: NDUFAF3
Entrez ID		25915	29078
HPRD ID		16809	10795
Ensembl ID		ENSG00000178057	ENSG00000123545
Uniprot IDs		A4FU71 Q9BU61 Q9Y3Z0	Q9P032
PDB IDs
Enriched GO Terms of Interacting Partners?
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