EFS and BLK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EFS	BLK
Description		embryonal Fyn-associated substrate	BLK proto-oncogene, Src family tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction Actin Filament Reorganization	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway
Pathways			RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases			Maturity onset diabetes of the young (MODY)
GWAS			Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Pulse pressure ( 27841878) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		24 interacting genes: ABI2 APP BCAR1 BLK CRK FYN LYST NCK1 NCK2 NLGN3 NPAS2 NUP155 OSTF1 PTK2 PTK2B PTPN12 SH2D3C SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBC ZNF417	18 interacting genes: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS ERBB2 FBXO7 FCGR2A FCGR2B PLCG2 SKAP2 STAT3 UBE3A
Entrez ID		10278	640
HPRD ID		09932	01866
Ensembl ID		ENSG00000100842	ENSG00000136573
Uniprot IDs		O43281	E9PJX5 P51451 Q05D26
PDB IDs
Enriched GO Terms of Interacting Partners?
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