BLK and BCAS2

Number of citations of the paper that reports this interaction (PubMedID 12406557)
1

Data Source:
HPRD (in vitro, two hybrid)

		BLK	BCAS2
Description		BLK proto-oncogene, Src family tyrosine kinase	BCAS2 pre-mRNA processing factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	mRNA Splicing - Major Pathway
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Pulse pressure ( 27841878) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		18 interacting genes: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS ERBB2 FBXO7 FCGR2A FCGR2B PLCG2 SKAP2 STAT3 UBE3A	19 interacting genes: AIMP2 BLK CDC5L EP300 ESR1 ESR2 GOLGA2 HGS IKZF3 KRT40 PGR POT1 PPARG SF1 SNRNP200 TCF4 TRAF1 TXNRD2 UBC
Entrez ID		640	10286
HPRD ID		01866	05777
Ensembl ID		ENSG00000136573	ENSG00000116752
Uniprot IDs		E9PJX5 P51451 Q05D26	B2R7W3 O75934
PDB IDs			5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV
Enriched GO Terms of Interacting Partners?
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