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LNX1 and CGN
Number of citations of the paper that reports this interaction (PMID
22889411
)
1
Data Source:
BioGRID
(two hybrid)
LNX1
CGN
Gene Name
ligand of numb-protein X 1, E3 ubiquitin protein ligase
cingulin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Tight Junction
Myosin Complex
Cell Junction
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
PDZ Domain Binding
Motor Activity
Actin Binding
Protein Binding
Microtubule Binding
Biological Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Homooligomerization
Microtubule Cytoskeleton Organization
Epithelial Cell Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Biological_process
Metabolic Process
Tight Junction Assembly
Pathways
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
DNA methylation (variation) (
23725790
)
Protein-Protein Interactions
218 interactors:
ABCA1
ABCB1
ABR
ACAT2
ACY3
ADRA1D
AGTRAP
AIDA
AIMP2
AKIRIN2
ALDOC
ALKBH3
AMMECR1L
APIP
APOL4
APP
ARHGAP6
ARHGEF16
ARVCF
ATPAF2
ATRIP
AURKC
BCR
BLVRA
BPIFA1
C1QTNF1
CA8
CALCOCO2
CAMK2N2
CATSPERD
CCDC101
CCDC102B
CCDC114
CCDC85B
CDA
CDC42EP4
CEP72
CGN
CIB3
CIRBP
CITED1
CLDN1
CLDN17
CLDN2
CLK2
COIL
CPNE2
CTBP1
CTNND2
CTSO
CUTC
CXADR
DAB1
DAPK1
DCTD
DCUN1D5
DDX17
DEPTOR
DNPEP
DOCK9
DPF2
DVL3
EBF4
EHMT2
EIF4H
ENOX1
EPHB3
EXOC8
FAM118A
FAM124A
FAM212B
FAM9B
FBP1
FBXL12
FHL3
GAS2L2
GDI1
GIPR
GJD4
GOLPH3L
GPR142
GRB2
GRIN1
HMBOX1
HOMEZ
HSBP1
HTR2B
HUNK
IGSF5
IL3RA
ILF3
INSC
ISCU
JOSD1
KALRN
KCNA4
KCTD1
KCTD13
KCTD17
KCTD6
KHDRBS3
KIAA1598
KLHL12
KRT15
KRTAP4-12
KRTAP4-2
KRTAP9-2
KXD1
LCLAT1
LDOC1
LGALS14
LGR6
LNX2
LRRC3B
LSM2
MAGEA11
MAGEB18
MAPK9
MEMO1
METTL21A
MRFAP1L1
MRPS24
MTMR9
MTUS2
MUSTN1
MVB12B
NADK
NAGK
NCK2
NECAB2
NEK6
NKD2
NME7
NOTCH2NL
NRCAM
NUDT14
NUMB
NUP37
NXT2
ORMDL3
OSBP2
OSGIN1
PAFAH1B3
PAICS
PBK
PBLD
PCBD1
PDZRN3
PDZRN4
PKDREJ
PKM
PKP4
POMGNT1
PPIA
PPID
PQBP1
PRR13
PTGIR
PTS
RABAC1
RAD51D
RAD54B
RBMX
RBMY1A1
RFPL3
ROBO3
ROPN1
RPIA
RUFY4
RUVBL2
SAPCD1
SAT1
SCLT1
SDK1
SLC6A15
SLC6A5
SNCB
SNRNP25
SNRPF
SPHKAP
SRSF1
SSNA1
SSTR3
STAC2
STRN
STX5
SUV39H1
SUV39H2
TBCEL
THAP7
TIFA
TMEM14C
TNFRSF18
TPM4
TRAF2
TRIM23
TRIM39
TRIM54
TRIP13
TRMT12
TSC2
TSC22D4
TSSK3
TYRO3
UBE2D2
ULK2
VCP
VRK2
WAC
WNT8A
WWP1
ZADH2
ZBTB43
ZBTB8A
ZCCHC10
ZFP64
ZNF581
ZNF593
6 interactors:
ARHGEF2
F11R
LNX1
TJP1
TJP2
YWHAG
Entrez ID
84708
57530
HPRD ID
17287
10827
Ensembl ID
ENSG00000072201
ENSG00000143375
Uniprot IDs
Q8TBB1
Q9P2M7
PDB IDs
3B76
Enriched GO Terms of Interacting Partners
?
Cellular Component Assembly
Protein Homooligomerization
Protein Oligomerization
Protein Complex Assembly
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cellular Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Regulation Of Cellular Component Organization
Cellular Aromatic Compound Metabolic Process
Regulation Of Rho Protein Signal Transduction
Response To Stimulus
Developmental Process
Cellular Metabolic Process
Peptidyl-lysine Dimethylation
Heterocycle Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Neutrophil Degranulation
Cellular Response To Stimulus
Viral Process
Programmed Cell Death
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Splicing
Cellular Nitrogen Compound Metabolic Process
Protein Tetramerization
Cell Death
Apoptotic Process
Death
Neuron Recognition
Cell Communication
Signaling
Regulation Of Neutrophil Degranulation
Negative Regulation Of Neutrophil Activation
Viral Release From Host Cell
Regulation Of Rho GTPase Activity
Cell-cell Junction Organization
Protein Autophosphorylation
Response To Abiotic Stimulus
Organelle Organization
Regulation Of Cell Morphogenesis
Nitrogen Compound Metabolic Process
Axon Midline Choice Point Recognition
Positive Regulation Of Rho GTPase Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Homodimerization Activity
Regulation Of Ras Protein Signal Transduction
Protein Heterooligomerization
Biosynthetic Process
Establishment Of Endothelial Intestinal Barrier
Establishment Of Endothelial Barrier
Endothelial Cell Development
Endothelial Cell Differentiation
Endothelium Development
Epithelial Cell Development
Intestinal Absorption
Hippo Signaling
Regulation Of Membrane Permeability
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Response To Organic Substance
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Execution Phase Of Apoptosis
Epithelial Cell Differentiation
Cell-cell Signaling Involved In Cell-cell Junction Organization
Cell Differentiation
Digestion
Cell-cell Junction Assembly
Intracellular Signal Transduction
Cellular Response To Organic Substance
Cellular Response To Muramyl Dipeptide
Membrane Organization
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To Magnetism
Cell Junction Assembly
Regulation Of Organelle Organization
Cell-cell Junction Organization
Epithelium Development
Response To Abiotic Stimulus
Anatomical Structure Development
Regulation Of Rho GTPase Activity
Regulation Of Response To Osmotic Stress
Cellular Hyperosmotic Response
Blood Circulation
Signal Transduction
Cellular Response To Peptide
Regulation Of Rho Protein Signal Transduction
Apoptotic Signaling Pathway
Developmental Process
Cellular Protein Localization
Negative Regulation Of Vascular Permeability
Negative Regulation Of Rho GTPase Activity
Signaling
Negative Regulation Of Necroptotic Process
Cell Communication
Establishment Of Protein Localization
Positive Regulation Of Rap GTPase Activity
Tagcloud
?
ac
attenuate
believed
blots
caspase
cerebellar
cho
cytochrome
cytosol
cytosolic
devd
ensuing
extracts
fmk
granule
hydroxydopamine
involves
lacking
laddering
mitochondria
neurotoxicity
ohda
pna
points
precedes
protease
reveal
ultimately
zvad
Tagcloud (Difference)
?
ac
attenuate
believed
blots
caspase
cerebellar
cho
cytochrome
cytosol
cytosolic
devd
ensuing
extracts
fmk
granule
hydroxydopamine
involves
lacking
laddering
mitochondria
neurotoxicity
ohda
pna
points
precedes
protease
reveal
ultimately
zvad
Tagcloud (Intersection)
?