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LNX1 and DVL3
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
LNX1
DVL3
Gene Name
ligand of numb-protein X 1, E3 ubiquitin protein ligase
dishevelled segment polarity protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
PDZ Domain Binding
Protease Binding
Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Protein Heterodimerization Activity
Biological Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Homooligomerization
Positive Regulation Of Protein Phosphorylation
Outflow Tract Septum Morphogenesis
Wnt Signaling Pathway
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT mediated activation of DVL
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by Wnt
Signaling by WNT in cancer
PCP/CE pathway
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
DNA methylation (variation) (
23725790
)
Major depressive disorder (
22472876
)
Protein-Protein Interactions
218 interactors:
ABCA1
ABCB1
ABR
ACAT2
ACY3
ADRA1D
AGTRAP
AIDA
AIMP2
AKIRIN2
ALDOC
ALKBH3
AMMECR1L
APIP
APOL4
APP
ARHGAP6
ARHGEF16
ARVCF
ATPAF2
ATRIP
AURKC
BCR
BLVRA
BPIFA1
C1QTNF1
CA8
CALCOCO2
CAMK2N2
CATSPERD
CCDC101
CCDC102B
CCDC114
CCDC85B
CDA
CDC42EP4
CEP72
CGN
CIB3
CIRBP
CITED1
CLDN1
CLDN17
CLDN2
CLK2
COIL
CPNE2
CTBP1
CTNND2
CTSO
CUTC
CXADR
DAB1
DAPK1
DCTD
DCUN1D5
DDX17
DEPTOR
DNPEP
DOCK9
DPF2
DVL3
EBF4
EHMT2
EIF4H
ENOX1
EPHB3
EXOC8
FAM118A
FAM124A
FAM212B
FAM9B
FBP1
FBXL12
FHL3
GAS2L2
GDI1
GIPR
GJD4
GOLPH3L
GPR142
GRB2
GRIN1
HMBOX1
HOMEZ
HSBP1
HTR2B
HUNK
IGSF5
IL3RA
ILF3
INSC
ISCU
JOSD1
KALRN
KCNA4
KCTD1
KCTD13
KCTD17
KCTD6
KHDRBS3
KIAA1598
KLHL12
KRT15
KRTAP4-12
KRTAP4-2
KRTAP9-2
KXD1
LCLAT1
LDOC1
LGALS14
LGR6
LNX2
LRRC3B
LSM2
MAGEA11
MAGEB18
MAPK9
MEMO1
METTL21A
MRFAP1L1
MRPS24
MTMR9
MTUS2
MUSTN1
MVB12B
NADK
NAGK
NCK2
NECAB2
NEK6
NKD2
NME7
NOTCH2NL
NRCAM
NUDT14
NUMB
NUP37
NXT2
ORMDL3
OSBP2
OSGIN1
PAFAH1B3
PAICS
PBK
PBLD
PCBD1
PDZRN3
PDZRN4
PKDREJ
PKM
PKP4
POMGNT1
PPIA
PPID
PQBP1
PRR13
PTGIR
PTS
RABAC1
RAD51D
RAD54B
RBMX
RBMY1A1
RFPL3
ROBO3
ROPN1
RPIA
RUFY4
RUVBL2
SAPCD1
SAT1
SCLT1
SDK1
SLC6A15
SLC6A5
SNCB
SNRNP25
SNRPF
SPHKAP
SRSF1
SSNA1
SSTR3
STAC2
STRN
STX5
SUV39H1
SUV39H2
TBCEL
THAP7
TIFA
TMEM14C
TNFRSF18
TPM4
TRAF2
TRIM23
TRIM39
TRIM54
TRIP13
TRMT12
TSC2
TSC22D4
TSSK3
TYRO3
UBE2D2
ULK2
VCP
VRK2
WAC
WNT8A
WWP1
ZADH2
ZBTB43
ZBTB8A
ZCCHC10
ZFP64
ZNF581
ZNF593
48 interactors:
ADAP1
AXIN1
BAHD1
C8orf33
CCNK
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
DAB2
DIDO1
DPPA2
DVL1
ENKD1
FAM13C
KAT7
KLF3
KLHL12
LNX1
LRRK2
LY6H
MARK2
MATN2
NKD1
NOL12
NXF1
PIK3CB
PITX1
PLN
PPM1A
PPP2CA
PRPF3
PSMF1
RPS10
RWDD2B
SNX22
STOM
SYT6
TNFAIP8L1
UTP3
VANGL1
WT1
YTHDC1
ZBTB48
ZNF264
ZNF408
ZNF512B
ZNF697
Entrez ID
84708
1857
HPRD ID
17287
03222
Ensembl ID
ENSG00000072201
ENSG00000161202
Uniprot IDs
Q8TBB1
Q92997
PDB IDs
3B76
Enriched GO Terms of Interacting Partners
?
Cellular Component Assembly
Protein Homooligomerization
Protein Oligomerization
Protein Complex Assembly
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cellular Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Regulation Of Cellular Component Organization
Cellular Aromatic Compound Metabolic Process
Regulation Of Rho Protein Signal Transduction
Response To Stimulus
Developmental Process
Cellular Metabolic Process
Peptidyl-lysine Dimethylation
Heterocycle Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Neutrophil Degranulation
Cellular Response To Stimulus
Viral Process
Programmed Cell Death
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Splicing
Cellular Nitrogen Compound Metabolic Process
Protein Tetramerization
Cell Death
Apoptotic Process
Death
Neuron Recognition
Cell Communication
Signaling
Regulation Of Neutrophil Degranulation
Negative Regulation Of Neutrophil Activation
Viral Release From Host Cell
Regulation Of Rho GTPase Activity
Cell-cell Junction Organization
Protein Autophosphorylation
Response To Abiotic Stimulus
Organelle Organization
Regulation Of Cell Morphogenesis
Nitrogen Compound Metabolic Process
Axon Midline Choice Point Recognition
Positive Regulation Of Rho GTPase Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Homodimerization Activity
Regulation Of Ras Protein Signal Transduction
Protein Heterooligomerization
Biosynthetic Process
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Wnt Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Gene Expression
RNA Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Transcription, DNA-templated
Nitrogen Compound Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cell Morphogenesis
Regulation Of Proteolysis
Regulation Of Cellular Component Organization
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Protein Modification Process
Macromolecule Biosynthetic Process
Negative Regulation Of Binding
Regulation Of Gene Expression
Cellular Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transferase Activity
Regulation Of Transcription, DNA-templated
Regulation Of Kinase Activity
Protein Complex Assembly
Tagcloud
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Difference)
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Intersection)
?