LNX1 and ABR

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		LNX1	ABR
Gene Name		ligand of numb-protein X 1, E3 ubiquitin protein ligase	active BCR-related
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rac GTPase Activator Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Neutrophil Degranulation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593	5 interactors: ADRA1A APP ECT2 ERBB2IP LNX1
Entrez ID		84708	29
HPRD ID		17287	02649
Ensembl ID		ENSG00000072201	ENSG00000159842
Uniprot IDs		Q8TBB1	B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60
PDB IDs		3B76
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process	Cell Growth Growth Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Basal Protein Localization Synaptic Growth At Neuromuscular Junction Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Collateral Sprouting In Absence Of Injury Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Pilomotor Reflex Cell Death Death Positive Regulation Of Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Protein Homooligomerization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Axon Choice Point Recognition Micturition Positive Regulation Of Cardiac Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Neuron Remodeling Positive Regulation Of Action Potential Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Heart Rate Regulation Of Phosphorus Metabolic Process Positive Regulation Of Striated Muscle Contraction Intracellular Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Systemic Arterial Blood Pressure Activation Of Rac GTPase Activity Cellular Metal Ion Homeostasis Adrenergic Receptor Signaling Pathway Response To Oxidative Stress Positive Regulation Of Synaptic Transmission, GABAergic Protein Oligomerization Cellular Cation Homeostasis Response To Radiation
Tagcloud ?			amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves
Tagcloud (Difference) ?			amplitude averaged bounded coefficients comparable components considerably deviation envelope exceeded fit intersubject intrasubject latency measurement measures middle mlr occasions oddball pa subject tended terms variability variation waveform waveforms waves
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