RBBP4 and SAP30

Number of citations of the paper that reports this interaction (PMID 9651585)
107

Data Source:
HPRD (in vitro, in vivo)

		RBBP4	SAP30
Gene Name		retinoblastoma binding protein 4	Sin3A-associated protein, 30kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex	Histone Deacetylase Complex Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Skeletal Muscle Cell Differentiation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events	NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6	27 interactors: ARID4A BRMS1 BRMS1L CIR1 HBP1 HDAC1 HDAC2 HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 HTT ID3 ING1 LINC00152 MXD1 NCOR1 NCOR2 PCBD1 RBBP4 RBBP7 RBP1 SAMSN1 SAP30BP SIN3A YY1 ZNF395
Entrez ID		5928	8819
HPRD ID		04232	04540
Ensembl ID		ENSG00000162521	ENSG00000164105
Uniprot IDs		Q09028	O75446
PDB IDs		2XU7 3GFC	2KDP
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process	Chromosome Organization Negative Regulation Of Gene Expression Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Gene Expression Heterocycle Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Metabolic Process Histone Deacetylation Histone Modification Protein Deacetylation ATP-dependent Chromatin Remodeling Rhythmic Process Histone H3-K9 Modification Transcription From RNA Polymerase II Promoter Circadian Rhythm Chromatin Remodeling CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Homeostatic Process Nucleosome Assembly Cellular Metabolic Process Chromatin Assembly Establishment Of Sertoli Cell Barrier
Tagcloud ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Difference) ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Intersection) ?