RBBP4 and BCL11B

Number of citations of the paper that reports this interaction (PMID 16091750)
36

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RBBP4	BCL11B
Gene Name		retinoblastoma binding protein 4	B-cell CLL/lymphoma 11B (zinc finger protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle	Keratinocyte Development Epithelial Cell Morphogenesis Transcription, DNA-templated Negative Regulation Of Cell Proliferation Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive T Cell Selection Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Alpha-beta T Cell Differentiation Thymus Development Olfactory Bulb Axon Guidance
Pathways		Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events
Drugs
Diseases
GWAS			Aortic stiffness ( 22068335) Corneal curvature ( 22969067)
Protein-Protein Interactions		50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6	9 interactors: CBX5 MBD3 MTA2 NR2F1 NR2F2 RBBP4 RBBP7 SP1 SUV39H1
Entrez ID		5928	64919
HPRD ID		04232	05950
Ensembl ID		ENSG00000162521	ENSG00000127152
Uniprot IDs		Q09028	L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0
PDB IDs		2XU7 3GFC
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process	Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Assembly Or Disassembly RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gene Expression CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Silencing Histone Exchange DNA Replication-independent Nucleosome Assembly Centromere Complex Assembly Histone Modification Biosynthetic Process Sequestering Of Nodal From Receptor Via Nodal Binding Radial Pattern Formation Pattern Specification Process Gene Silencing Steroid Hormone Mediated Signaling Pathway In Utero Embryonic Development Negative Regulation Of Nodal Signaling Pathway Cellular Heat Acclimation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
Tagcloud ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann mta1 nucleosome nurd nurf55 overlaps pair pocket propeller recognizing remodeling repression su top	cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 mll2 mutational notch1 notch2 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?		lymphoblastic phf6