RBBP4 and HAT1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RBBP4	HAT1
Gene Name		retinoblastoma binding protein 4	histone acetyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding	Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle	DNA Packaging Chromatin Organization DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Silencing At Telomere Internal Protein Amino Acid Acetylation Response To Nutrient Histone H4 Acetylation
Pathways		Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6	13 interactors: ACAA1 HIST1H4A HIST2H2AC HIST2H4A HIST3H3 HIST4H4 MEOX2 RBBP4 REL SMAD7 TCF4 TNFAIP1 YWHAQ
Entrez ID		5928	8520
HPRD ID		04232	04339
Ensembl ID		ENSG00000162521	ENSG00000128708
Uniprot IDs		Q09028	O14929
PDB IDs		2XU7 3GFC	2P0W
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process	DNA Replication-dependent Nucleosome Assembly Histone H4-K20 Demethylation CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Centromere Complex Assembly Protein-DNA Complex Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Methylation On Cytosine ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Negative Regulation Of Gene Expression Chromatin Silencing At RDNA Regulation Of Megakaryocyte Differentiation Nucleosome Assembly DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Nucleosome Organization Chromatin Silencing Histone Lysine Demethylation Histone Demethylation Chromatin Assembly Or Disassembly Protein Demethylation Negative Regulation Of Biosynthetic Process Chromatin Remodeling DNA Packaging Regulation Of Gene Expression, Epigenetic DNA Methylation Demethylation Chromosome Organization Nucleobase-containing Compound Metabolic Process DNA Conformation Change Negative Regulation Of Myeloid Cell Differentiation Cellular Macromolecular Complex Assembly DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Gene Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process
Tagcloud ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley
Tagcloud (Difference) ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	21mt1 21nt 21pt biochem cancerous confocal dnmt1 dnmt3a ductal enrichment global h16n2 h3k9me3 h4ac heterochromatin hyperplasia hypoacetylation hypomethylation immunofluorescent inc mark oncogenesis p1 pericentric periodicals periphery repressive tp53 wiley
Tagcloud (Intersection) ?