RBBP4 and RPN2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RBBP4	RPN2
Gene Name		retinoblastoma binding protein 4	ribophorin II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex	Autophagic Vacuole Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Ribosome Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle	Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Aging Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Drug Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6	8 interactors: ADRM1 EZH2 FBN3 NDRG1 NGFR RBBP4 RCHY1 RHOA
Entrez ID		5928	6185
HPRD ID		04232	01609
Ensembl ID		ENSG00000162521	ENSG00000118705
Uniprot IDs		Q09028	P04844
PDB IDs		2XU7 3GFC
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process	Regulation Of Cell Cycle Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Axonogenesis Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Neurogenesis Regulation Of Proteolysis Negative Regulation Of Cell Projection Organization Regulation Of Neurogenesis Negative Regulation Of Hair Follicle Development Skeletal Muscle Satellite Cell Migration Regulation Of Axonogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Hair Cycle Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Neuron Differentiation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Positive Regulation Of Spindle Checkpoint Cleavage Furrow Formation Regulation Of Protein Metabolic Process Central Nervous System Development Nervous System Development G1 To G0 Transition Protein Complex Assembly Cell Cycle Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cell Cycle Checkpoint Proteasome Assembly Histone H3-K27 Methylation Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Difference) ?		bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top	acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Intersection) ?