CDC42 and PIK3R1

Data Source:
HPRD (in vitro, in vivo)

		CDC42	PIK3R1
Description		cell division cycle 42	phosphoinositide-3-kinase regulatory subunit 1
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GO Annotations	Cellular Component	Golgi Membrane Storage Vacuole Cytoplasm Endoplasmic Reticulum Membrane Centrosome Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Golgi Transport Complex Secretory Granule Filopodium Midbody Leading Edge Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Dendritic Spine Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Mitotic Spindle Schaffer Collateral - CA1 Synapse	Nucleus Cytoplasm Cis-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Transcription Factor Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Sprouting Angiogenesis Cardiac Conduction System Development Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Cell Migration Protein Ubiquitination Substantia Nigra Development Cell Projection Assembly Actin Cytoskeleton Organization Macrophage Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokinesis Cdc42 Protein Signal Transduction Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Interleukin-12-mediated Signaling Pathway Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Viral RNA Genome Replication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA Replication Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Pinocytosis Neuron Fate Determination Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Submandibular Salivary Gland Formation Dendritic Spine Morphogenesis Cellular Response To Interferon-gamma Organelle Transport Along Microtubule Actin Filament Branching Positive Regulation Of Intracellular Protein Transport Regulation Of Modification Of Postsynaptic Structure Modification Of Synaptic Structure Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Cytoskeleton Reorganization	Cellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Protein Import Into Nucleus Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lamellipodium Assembly Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Cytokine-mediated Signaling Pathway Platelet Activation B Cell Differentiation Positive Regulation Of Cell Migration T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Substrate Adhesion-dependent Cell Spreading Cellular Response To UV Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Growth Hormone Receptor Signaling Pathway Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		GPVI-mediated activation cascade EGFR downregulation Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate	Isoprenaline SF1126 Enzastaurin Wortmannin
Diseases
GWAS		Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483) Uterine fibroids ( 31488892 31249589 30194396 31649266) Uterine fibroids (MTAG) ( 31488892)	Alzheimer's disease biomarkers ( 23419831) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Cleft lip with or without cleft palate ( 28054174) Corneal astigmatism ( 30306274) Crohn's disease ( 32581322) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip minimal joint space width ( 27701424) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Menarche (age at onset) ( 23599027) Offspring birth weight ( 31043758) Red cell distribution width ( 32888494 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 29083408 32203549) Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		382 interacting genes: A2M AARS1 ACADM ACO1 ACO2 ACOT7 ACTR3 ADRM1 AGAP1 AGAP2 AHSG AKR1B1 ALDH18A1 ANAPC13 ANXA11 ANXA2 AP3D1 APEX1 APOH ARAP1 ARAP2 ARG1 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP40 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ATP5F1C ATP5IF1 ATP5MF ATP5PD ATP6V1A BAIAP2 BCAP31 BCCIP BCR BIRC2 BLMH BNIP2 BTF3 BZW2 CALML5 CAPNS1 CAPZB CARHSP1 CASP14 CASP3 CASP7 CBLL1 CBX3 CCN1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC5L CDH1 CDKN2A CFHR4 CGN CMPK1 CNBP CNOT1 COL1A1 COMT COPA COPE COPG1 CPN1 CRIP2 CSE1L CSN2 CSPG4 CTNNA1 DEF6 DEK DHFR DIAPH1 DIAPH2 DIAPH3 DNMBP DOCK7 DOCK8 DOCK9 DPYSL2 DSG1 DSP ECHS1 EDC4 EDF1 EEF1E1 EEF1G EHD2 EHD4 EIF2AK2 EIF3D EIF3F EIF5 EIF5B EPHA2 EPRS1 ERCC3 ERG28 ERICH6 ERRFI1 ETFA FAM13B FGD1 FGD2 FGD3 FGD4 FKBP10 FKBP1A FKBP3 FLNA FLNC FMN2 FMNL2 FNBP1 FNBP1L FTH1 G6PD GALNT2 GART GDI1 GIT1 GIT2 GLS GMIP GNB1 GRB2 GRWD1 GSR GSTM5 H1-10 H1-5 H2BC13 HADH HADHB HDAC7 HDLBP HERC2 HLA-G HMGN1 HNRNPAB HNRNPUL2 HSD17B10 HYOU1 IARS1 IGF2BP1 IPO5 IQGAP1 IQGAP2 ITSN1 JPT2 KARS1 KAT5 KHDRBS1 KIAA2026 KPNA2 KTN1 KYNU LARS1 LCK LGALS1 LGALS7 LONP1 LRIF1 LRP2 LYZ MAP2K3 MAP3K10 MAP3K11 MAP3K19 MAP3K4 MAP4 MAPRE1 MARCKSL1 MARK4 MASTL MATR3 MCF2L MCM3AP MCM6 MCM7 MDH1 MDK METAP2 MRM1 MRPL49 MSH2 MT-CO1 MTDH MUC12 MYO1C MYO6 MYO9A NAA15 NASP NCAPD2 NCF2 NEK6 NIBAN2 NOP2 NPLOC4 NQO1 NUDT21 NUP155 OCRL OLA1 OPHN1 P3H1 PABPC4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARD3 PARD6A PARD6B PARD6G PAXX PCM1 PCNP PDCD5 PDE6C PDE6D PGD PGGT1B PHAX PHB2 PHPT1 PICALM PIK3R1 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PMS1 PPP2R1A PRDX3 PREX2 PRKCA PRKCG PRKCI PRKCZ PSAT1 PSIP1 PSMB1 PSMC5 PSMC6 PSMD11 PSMD12 PSMD3 PSME3 PXDN RAC2 RAP1GDS1 RARS1 RASGRF2 RBM39 RBM8A RHOJ RIOK3 RO60 RPL22 RPL23 RPS15 RPS21 RPS6KB1 RRM1 S100A9 SDHA SEPTIN2 SERPINB1 SERPINB2 SERPINB3 SF1 SF3A2 SH3BGRL3 SH3D19 SLC16A3 SMC2 SNRNP70 SPATA13 SRGAP1 SRM SRP72 SRSF1 SSB SSX2IP ST13 STARD8 STAT1 STAU1 STMN2 SYNE1 TBC1D3F TBCA TCEAL3 TIAM1 TMED10 TMED9 TMOD3 TMX1 TNFRSF10B TNK2 TOR1AIP1 TP53 TPD52L2 TPM1 TRAF2 TRAF7 TRIM28 TRIM45 TRIM60 TRIO TRIP10 TRRAP TSFM TTC12 TUBB3 TXNL1 TYMS U2AF2 UBC UBE2L3 UBR1 UGDH UNC119 USP6 VARS1 VASP VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP XPO1 YARS1 YWHAH ZNF175 ZNF234 ZNF415 ZNF420 ZNF622	175 interacting genes: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 APPL1 AR ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BLK BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CLNK CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGF EGFR ENKUR EPHA2 EPOR ERAS ERBB2 ERBB3 ERBB4 ESR1 EZR FASLG FCGR2A FER FES FGFR1 FLT1 FYN GAB1 GAB2 GAB3 GHR GP1BA GRB2 GSPT1 GTF2H1 HCK HCST HGS HOXA1 HRAS HTT IFNAR1 IGF1R IKZF3 IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KBTBD2 KHDRBS1 KIT LAT LCK LNX2 LRRK2 MAPK8 MAPT MET MME MST1R MYO16 NFKBIA NTRK1 NTRK2 NUP85 NYAP1 NYAP2 PASK PDE4D PDGFB PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PRMT8 PROM1 PSEN1 PSMB5 PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RASD2 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SQSTM1 SRC SSTR2 STAT3 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TNS4 TOM1L1 TRAT1 TSHR TTR TUB TUBA1B TUBG1 TXK TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG YWHAZ
Entrez ID		998	5295
HPRD ID		00309	01381
Ensembl ID		ENSG00000070831	ENSG00000145675
Uniprot IDs		A0A024RAA5 A0A024RAE6 P60953	A0A2X0SFG1 P27986
PDB IDs		1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL 6SIU 6SUP 6TKY 6TKZ	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 5GJI 5ITD 5M6U 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBT 5UK8 5UKJ 5UL1 5VLR 5XGH 5XGI 5XGJ 6NCT 6PYR 6PYU
Enriched GO Terms of Interacting Partners?
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