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PIK3R1 and BRCA1
Data Source:
BioGRID
(unspecified method)
PIK3R1
BRCA1
Description
phosphoinositide-3-kinase regulatory subunit 1
BRCA1 DNA repair associated
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Ubiquitin Ligase Complex
Lateral Element
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Gamma-tubulin Ring Complex
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
Ribonucleoprotein Complex
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
RNA Polymerase Binding
Biological Process
Cellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Protein Import Into Nucleus
Phosphatidylinositol Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Cytokine-mediated Signaling Pathway
Platelet Activation
B Cell Differentiation
Positive Regulation Of Cell Migration
T Cell Costimulation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Protein Stabilization
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Filopodium Assembly
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Localization To Plasma Membrane
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
Postreplication Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase III
Fatty Acid Biosynthetic Process
Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Chromosome Segregation
Centrosome Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Dosage Compensation By Inactivation Of X Chromosome
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Histone Acetylation
Negative Regulation Of Histone Acetylation
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Response To Estrogen
Regulation Of DNA Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Protein Autoubiquitination
Negative Regulation Of G0 To G1 Transition
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Tumor Necrosis Factor
Cellular Response To Indole-3-methanol
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Histone H4-K16 Acetylation
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Extra-nuclear estrogen signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Isoprenaline
SF1126
Enzastaurin
Wortmannin
Diseases
Breast cancer
Ovarian cancer
GWAS
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Cleft lip with or without cleft palate (
28054174
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
31152163
30604766
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
29083408
32203549
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Interacting Genes
175 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNS4
TOM1L1
TRAT1
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
YWHAZ
318 interacting genes:
ABL1
ABLIM3
ABRAXAS1
ACACA
ACTG1
ACTN3
AHR
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
C2CD6
CABYR
CASP3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERCC6
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPHLN1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
WDR6
WNT2B
WRN
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
Entrez ID
5295
672
HPRD ID
01381
00218
Ensembl ID
ENSG00000145675
ENSG00000012048
Uniprot IDs
A0A2X0SFG1
P27986
A0A024R1V0
P38398
PDB IDs
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
Enriched GO Terms of Interacting Partners
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