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PIK3R1 and IL13
Data Source:
HPRD
(in vivo)
PIK3R1
IL13
Description
phosphoinositide-3-kinase regulatory subunit 1
interleukin 13
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Extracellular Region
Extracellular Space
Cytoplasm
External Side Of Plasma Membrane
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Cytokine Activity
Interleukin-13 Receptor Binding
Protein Binding
Biological Process
Cellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Protein Import Into Nucleus
Phosphatidylinositol Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Cytokine-mediated Signaling Pathway
Platelet Activation
B Cell Differentiation
Positive Regulation Of Cell Migration
T Cell Costimulation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Protein Stabilization
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Filopodium Assembly
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Localization To Plasma Membrane
Microglial Cell Activation
Positive Regulation Of Immunoglobulin Production
Inflammatory Response
Immune Response
Regulation Of Proton Transport
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Positive Regulation Of B Cell Proliferation
Response To Lipopolysaccharide
Positive Regulation Of Connective Tissue Growth Factor Production
Positive Regulation Of Interleukin-10 Production
Negative Regulation Of NAD(P)H Oxidase Activity
Response To Nicotine
Macrophage Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Macrophage Activation
Positive Regulation Of Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Protein Secretion
Negative Regulation Of Inflammatory Response
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Mechanical Stimulus
Negative Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuron Death
Negative Regulation Of Lung Ciliated Cell Differentiation
Positive Regulation Of Lung Goblet Cell Differentiation
Negative Regulation Of Complement-dependent Cytotoxicity
Positive Regulation Of Pancreatic Stellate Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Extra-nuclear estrogen signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Drugs
Isoprenaline
SF1126
Enzastaurin
Wortmannin
Cintredekin Besudotox
Lebrikizumab
Diseases
Asthma
Graft-versus-host disease
GWAS
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Cleft lip with or without cleft palate (
28054174
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
31152163
30604766
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
29083408
32203549
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Allergy (
27182965
)
Alopecia areata (
25608926
)
Asthma (
31361310
31959851
20860503
32296059
31619474
29785011
29273806
)
Asthma (childhood onset) (
24241537
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
23042114
23886662
25574825
26482879
23727859
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
22286212
24920014
)
IgE levels (
22075330
)
Inflammatory bowel disease (
23128233
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Psoriasis (
25903422
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
)
Rosacea symptom severity (
29771307
)
Interacting Genes
175 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNS4
TOM1L1
TRAT1
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
YWHAZ
5 interacting genes:
IL13RA1
IL13RA2
IL4R
PIK3R1
VCAM1
Entrez ID
5295
3596
HPRD ID
01381
00981
Ensembl ID
ENSG00000145675
ENSG00000169194
Uniprot IDs
A0A2X0SFG1
P27986
P35225
PDB IDs
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
1GA3
1IJZ
1IK0
1J9U
3BPO
3G6D
3ITR
3ITS
3L5W
3L5X
3LB6
4I77
4PS4
5E4E
5L6Y
Enriched GO Terms of Interacting Partners
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