NR1I3 and CHD9

Data Source:
HPRD (in vitro)

		NR1I3	CHD9
Description		nuclear receptor subfamily 1 group I member 3	chromodomain helicase DNA binding protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding DNA Helicase Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Regulation Of Lipid Metabolic Process DNA Duplex Unwinding
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock
Drugs		Doxylamine Meclizine Loperamide Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan
Diseases
GWAS		Blood metabolite levels ( 24816252)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Neutrophil count ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	5 interacting genes: ESR1 NR1I3 NR3C1 PPARA RXRA
Entrez ID		9970	80205
HPRD ID		04858	08570
Ensembl ID		ENSG00000143257	ENSG00000177200
Uniprot IDs		F1DAL4 Q14994	Q3L8U1
PDB IDs		1XV9 1XVP
Enriched GO Terms of Interacting Partners?
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