CHD9 and NR1I3

Data Source:
HPRD (in vitro)

		CHD9	NR1I3
Description		chromodomain helicase DNA binding protein 9	nuclear receptor subfamily 1 group I member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton
	Molecular Function	DNA Binding DNA Helicase Activity ATP Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of Lipid Metabolic Process DNA Duplex Unwinding	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock
Drugs			Doxylamine Meclizine Loperamide Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Neutrophil count ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Response to fenofibrate (triglyceride levels) ( 27002377)	Blood metabolite levels ( 24816252)
Interacting Genes		5 interacting genes: ESR1 NR1I3 NR3C1 PPARA RXRA	18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC
Entrez ID		80205	9970
HPRD ID		08570	04858
Ensembl ID		ENSG00000177200	ENSG00000143257
Uniprot IDs		Q3L8U1	F1DAL4 Q14994
PDB IDs			1XV9 1XVP
Enriched GO Terms of Interacting Partners?
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