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NR1I3 and PPARGC1A
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(two hybrid)
NR1I3
PPARGC1A
Description
nuclear receptor subfamily 1 group I member 3
PPARG coactivator 1 alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Chromatin
Nucleus
Nucleoplasm
PML Body
Cytosolic Ribosome
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Apical Dendrite
Subsarcolemmal Mitochondrion
Interfibrillar Mitochondrion
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific Double-stranded DNA Binding
DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Estrogen Receptor Binding
Nuclear Receptor Coactivator Activity
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Peroxisome Proliferator Activated Receptor Binding
Alpha-tubulin Binding
Sequence-specific DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Response To Reactive Oxygen Species
Autophagy Of Mitochondrion
Temperature Homeostasis
Cellular Glucose Homeostasis
Negative Regulation Of Protein Phosphorylation
Response To Dietary Excess
Response To Ischemia
Galactose Metabolic Process
Gluconeogenesis
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
MRNA Processing
Mitochondrion Organization
Aging
Digestion
Circadian Rhythm
Androgen Metabolic Process
RNA Splicing
Response To Cold
Positive Regulation Of Gene Expression
Positive Regulation Of Mitochondrion Organization
Skeletal Muscle Atrophy
Response To Muscle Activity
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Negative Regulation Of Smooth Muscle Cell Migration
Fatty Acid Oxidation
Cerebellum Development
Respiratory Electron Transport Chain
Forebrain Development
Circadian Regulation Of Gene Expression
Cellular Response To Oxidative Stress
Positive Regulation Of Histone Acetylation
Cellular Response To Potassium Ion
Response To Drug
Response To Starvation
Regulation Of Circadian Rhythm
Response To Leucine
Negative Regulation Of Neuron Apoptotic Process
Cellular Respiration
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Brown Fat Cell Differentiation
Positive Regulation Of DNA-binding Transcription Factor Activity
Flavone Metabolic Process
Adipose Tissue Development
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Nitrite
Cellular Response To Caffeine
Cellular Response To Fructose Stimulus
Cellular Response To Glucose Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Epinephrine
Response To Norepinephrine
Negative Regulation Of Mitochondrial Fission
Energy Homeostasis
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuron Death
Response To Metformin
Positive Regulation Of Cellular Respiration
Positive Regulation Of Mitochondrial DNA Metabolic Process
Positive Regulation Of Muscle Tissue Development
Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
Cellular Response To Ionomycin
Cellular Response To Resveratrol
Response To Methionine
Adaptive Thermogenesis
Positive Regulation Of Progesterone Biosynthetic Process
Negative Regulation Of Signaling Receptor Activity
Regulation Of NMDA Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Pathways
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
Circadian Clock
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Doxylamine
Meclizine
Loperamide
Ketoconazole
Atorvastatin
Pheniramine
Prasterone
16,17-Androstene-3-Ol
Resveratrol
Cholesterol
Phenolphthalein
3,20-Pregnanedione
Hexestrol
Triclosan
Diseases
GWAS
Blood metabolite levels (
24816252
)
Coffee consumption (
31046077
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Corneal astigmatism (
29422769
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Essential tremor (
27797806
)
Estimated glomerular filtration rate (
31152163
31015462
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lead levels (
26025379
)
Molar-incisor hypomineralization (
23918034
)
PR interval (
32439900
)
Refractive error (
32231278
)
Resting heart rate (
27798624
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
30285260
)
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) (
31557306
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
18 interacting genes:
CHD9
DNMT3L
FTH1
HNF4A
IGH
MAP4
MED1
NCOA1
NCOA3
NR0B2
POU1F1
PPARGC1A
PSMC4
PSMC5
RXRA
SNRPD3
SNX13
SRC
43 interacting genes:
CAPNS1
CDK6
CREBBP
ESR1
ESR2
ESRRA
ESRRG
FBXW7
GSK3B
HCFC1
HNF4A
LRPPRC
MAPK14
MED1
MED12
MED14
MED17
MYBBP1A
NCL
NCOA1
NCOA6
NDN
NR1H4
NR1I2
NR1I3
NR3C1
NRF1
PPARA
PPARD
PPARG
RARB
RXRA
SIRT1
SKP1
SRSF4
SRSF5
SRSF6
THRB
TP53
UBC
UBE2I
USF1
USF2
Entrez ID
9970
10891
HPRD ID
04858
05155
Ensembl ID
ENSG00000143257
ENSG00000109819
Uniprot IDs
F1DAL4
Q14994
A0A024R9Q9
Q9UBK2
PDB IDs
1XV9
1XVP
1XB7
3B1M
3CS8
3D24
3U9Q
3V9T
3V9V
4QJR
4QK4
5Q0I
5TWO
5UNJ
5Z5S
5Z6S
6AD9
6FZF
6FZP
6IZM
6IZN
6K0T
6KXX
6KXY
6LN4
6MS7
6NWK
6NWL
6W9K
6W9L
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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