TNFSF15 and OAT

Data Source:
BioGRID (affinity chromatography technology)

		TNFSF15	OAT
Description		TNF superfamily member 15	ornithine aminotransferase
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Ornithine-oxo-acid Transaminase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding Ornithine(lysine) Transaminase Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Visual Perception Cellular Amino Acid Biosynthetic Process Arginine Catabolic Process To Proline Via Ornithine Arginine Catabolic Process To Glutamate L-proline Biosynthetic Process
Pathways		TNFs bind their physiological receptors	Glutamate and glutamine metabolism
Drugs			Pyridoxal phosphate Ornithine Gabaculine Canaline
Diseases		Crohn's disease	Ornithinaemia
GWAS		Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		2 interacting genes: TNFRSF25 TNFRSF6B	3 interacting genes: NUDT3 SLC35F6 UBQLN4
Entrez ID		9966	4942
HPRD ID		04956	02021
Ensembl ID		ENSG00000181634	ENSG00000065154
Uniprot IDs		A0A0U5JA19 O95150	A0A140VJQ4 P04181
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8	1GBN 1OAT 2BYJ 2BYL 2CAN 2OAT 5VWO 6HX7 6OIA
Enriched GO Terms of Interacting Partners?
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