TNFSF15 and TNFRSF25

Data Source:
HPRD (in vivo)

		TNFSF15	TNFRSF25
Description		TNF superfamily member 15	TNF receptor superfamily member 25
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Crohn's disease
GWAS		Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		2 interacting genes: TNFRSF25 TNFRSF6B	8 interacting genes: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		9966	8718
HPRD ID		04956	04532
Ensembl ID		ENSG00000181634	ENSG00000215788
Uniprot IDs		A0A0U5JA19 O95150	Q93038
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8	5YGP 5YGS
Enriched GO Terms of Interacting Partners?
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