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CDC27 and FZR1
Data Source:
HPRD
(in vivo)
CDC27
FZR1
Description
cell division cycle 27
fizzy and cell division cycle 20 related 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Centrosome
Spindle
Cytosol
Mitotic Spindle
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Membrane
Molecular Function
Protein Binding
Protein Phosphatase Binding
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin Ligase Activator Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Cell Population Proliferation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Division
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Negative Regulation Of Cell Aging
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Diffusing capacity of carbon monoxide (
30694715
)
Red cell distribution width (
32888494
)
Interacting Genes
29 interacting genes:
ADNP
ANAPC10
ANAPC2
ANAPC4
ANAPC7
BUB1B
CASP3
CCNB1
CDC16
CDC20
CDC26
CKS1B
COMT
CTNNB1
DCPS
FZR1
GKN1
HOXC10
HSF2
MAD2L1
PIN1
PPP5C
PTEN
PTTG1
RB1
SKIL
SMAD2
SMAD3
UBE2S
96 interacting genes:
AKT1
AKT1S1
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC5
ANAPC7
ARNT
AURKA
BECN1
BEX1
BLID
BTRC
BUB1B
C7orf25
CCL5
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC20
CDC25A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2A
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PCLAF
PDGFRA
PLK1
PSMC3IP
PTP4A3
PTTG1
RASSF1
RBBP8
SASS6
SENP2
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
SRC
STK11
TEAD2
TERT
THRSP
TP53
UBE2C
UBE2D1
UBE2D3
UBE2K
UBE2S
Entrez ID
996
51343
HPRD ID
00304
04687
Ensembl ID
ENSG00000004897
ENSG00000105325
Uniprot IDs
B4DL80
G5EA36
P30260
Q9UM11
PDB IDs
3T1N
4RG6
4RG7
4RG9
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
4UI9
5L9T
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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