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CDC27 and ANAPC4
Data Source:
BioGRID
(pull down)
CDC27
ANAPC4
Description
cell division cycle 27
anaphase promoting complex subunit 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Centrosome
Spindle
Cytosol
Mitotic Spindle
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Periphery
Molecular Function
Protein Binding
Protein Phosphatase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Phosphatase Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Diffusing capacity of carbon monoxide (
30694715
)
Adult body size (
32376654
)
Body mass index (
29273807
)
Body size at age 10 (
32376654
)
General cognitive ability (
29844566
)
Heel bone mineral density (
30598549
)
Intelligence (MTAG) (
29326435
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Multisite chronic pain (
31194737
)
Weight (
20966902
)
Interacting Genes
29 interacting genes:
ADNP
ANAPC10
ANAPC2
ANAPC4
ANAPC7
BUB1B
CASP3
CCNB1
CDC16
CDC20
CDC26
CKS1B
COMT
CTNNB1
DCPS
FZR1
GKN1
HOXC10
HSF2
MAD2L1
PIN1
PPP5C
PTEN
PTTG1
RB1
SKIL
SMAD2
SMAD3
UBE2S
7 interacting genes:
ANAPC11
CDC20
CDC27
MAD2L1
MAD2L1BP
UBE2I
UBE2S
Entrez ID
996
29945
HPRD ID
00304
09505
Ensembl ID
ENSG00000004897
ENSG00000053900
Uniprot IDs
B4DL80
G5EA36
P30260
B3KN47
Q9UJX5
PDB IDs
3T1N
4RG6
4RG7
4RG9
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
4UI9
5A31
5BPW
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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