Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ANAPC4
Description
anaphase promoting complex subunit 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Periphery
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Phosphatase Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Body mass index (
29273807
)
Body size at age 10 (
32376654
)
General cognitive ability (
29844566
)
Heel bone mineral density (
30598549
)
Intelligence (MTAG) (
29326435
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Multisite chronic pain (
31194737
)
Weight (
20966902
)
Novel Interacting Genes
1 novel interacting genes:
SEPSECS
Interacting Genes
7 interacting genes:
ANAPC11
CDC20
CDC27
MAD2L1
MAD2L1BP
UBE2I
UBE2S
Entrez ID
29945
HPRD ID
09505
Ensembl ID
ENSG00000053900
Uniprot IDs
B3KN47
Q9UJX5
PDB IDs
4UI9
5A31
5BPW
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
?
Tagcloud
?