GOLGA5 and OCRL

Data Source:
HPRD (two hybrid)

		GOLGA5	OCRL
Description		golgin A5	OCRL inositol polyphosphate-5-phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Transport Vesicle Golgi Cisterna	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Small GTPase Binding Protein Homodimerization Activity	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Golgi Vesicle Transport	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly Membrane Organization
Pathways		Intra-Golgi traffic	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Rho GTPase cycle Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS		Body mass index ( 26426971)
Interacting Genes		4 interacting genes: CUX1 ITSN1 OCRL RAB1A	14 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1
Entrez ID		9950	4952
HPRD ID		06079	02395
Ensembl ID		ENSG00000066455	ENSG00000122126
Uniprot IDs		Q8TBA6	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs			2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?
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