TLK1 and CXCR5

Data Source:
BioGRID (biochemical)

		TLK1	CXCR5
Description		tousled like kinase 1	C-X-C motif chemokine receptor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Follicular lymphoma ( 25279986) Herpes simplex virus 7 U14 antibody levels ( 33204752) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 24076602 21833088) Primary biliary cholangitis ( 28425483 21399635 26394269) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) SjÃ¶gren's syndrome ( 24097067) Trunk fat mass ( 28552196) Vitiligo ( 22951725)
Interacting Genes		28 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	1 interacting genes: CXCL13
Entrez ID		9874	643
HPRD ID		12232	03367
Ensembl ID		ENSG00000198586	ENSG00000160683
Uniprot IDs		Q9UKI8	A0N0R2 A8K647 P32302 Q2YD84
PDB IDs
Enriched GO Terms of Interacting Partners?
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