EPM2AIP1 and TNKS

Data Source:
BioGRID (two hybrid)

		EPM2AIP1	TNKS
Description		EPM2A interacting protein 1	tankyrase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Pore Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Membrane Mitotic Spindle Pole
	Molecular Function	Protein Binding Identical Protein Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein ADP-ribosylase Activity
	Biological Process	Response To Insulin Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cellular Response To Nutrient Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Positive Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Pathways			TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Subjective response to lithium treatment ( 26503763) Triglyceride levels ( 32203549)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)
Interacting Genes		46 interacting genes: ACTN1 APPL2 ARHGEF5 C1orf50 CBFA2T3 CCNB1IP1 CNTROB CPSF7 DTX3 EMP2 EPM2A FHL3 GFAP HSF2BP KCTD1 KCTD9 KRT16 KRT75 LDB2 LIN52 LNX1 MAD2L1 MEOX2 MX1 NOC4L OTUD7B PICK1 PRTFDC1 PSMA7 RBMY1F RBMY1J REL SERPINF1 SWSAP1 TFIP11 TNFAIP1 TNKS TRA2B TRIM50 TRIM54 USP54 VPS52 ZBTB14 ZIM2 ZNF620 ZSCAN18	25 interacting genes: ADPRS ANKRD28 BABAM1 DISC1 EIF4A1 EPM2AIP1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 OARD1 POT1 PTEN SDCBP SH3BP5 TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A
Entrez ID		9852	8658
HPRD ID		07445	04490
Ensembl ID		ENSG00000178567	ENSG00000173273
Uniprot IDs		Q7L775	O95271
PDB IDs			2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ
Enriched GO Terms of Interacting Partners?
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