PLEKHM1 and PAFAH1B3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHM1	PAFAH1B3
Description		pleckstrin homology and RUN domain containing M1	platelet activating factor acetylhydrolase 1b catalytic subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Lysosomal Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Membrane
	Molecular Function	Metal Ion Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Autophagy Protein Transport Lysosome Localization Intracellular Signal Transduction Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly	Lipid Metabolic Process Spermatogenesis Nervous System Development Brain Development Lipid Catabolic Process
Pathways			COPI-independent Golgi-to-ER retrograde traffic
Drugs			(1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Male-pattern baldness ( 29146897 28196072) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)
Interacting Genes		9 interacting genes: BID EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9 TRIM54	36 interacting genes: BRD7 CCDC90B CHMP7 COPS6 CRMP1 DDX24 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 HSPH1 IGSF21 LNX1 LRIF1 MED31 MEI4 NIF3L1 PAFAH1B1 PAFAH1B2 PICK1 PLEKHM1 RBM48 SDCBP2 SETDB1 SUMO4 TERF1 TERF2IP TLE1 TP53 TUBB2A UNC119 XRCC6 ZBTB16 ZHX1
Entrez ID		9842	5050
HPRD ID		11439	04354
Ensembl ID		ENSG00000225190	ENSG00000079462
Uniprot IDs		Q9Y4G2	A0A024R0L6 Q15102
PDB IDs		5DPR 5DPS 5DPT 5DPW
Enriched GO Terms of Interacting Partners?
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