ATG13 and SMCR8

Data Source:
BioGRID (two hybrid)

		ATG13	SMCR8
Description		autophagy related 13	SMCR8-C9orf72 complex subunit
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GO Annotations	Cellular Component	Phagophore Assembly Site Mitochondrion Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Atg1/ULK1 Kinase Complex	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Autophagosome Assembly Mitophagy Macroautophagy Regulation Of Macroautophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)	Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C SMCR8	4 interacting genes: ATG13 C9orf72 TBK1 ULK1
Entrez ID		9776	140775
HPRD ID		13809	18075
Ensembl ID		ENSG00000175224	ENSG00000176994
Uniprot IDs		A8K0S6 O75143	Q8TEV9
PDB IDs		3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN	6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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