RAPGEF5 and ITGB8

Data Source:
BioGRID (affinity chromatography technology)

		RAPGEF5	ITGB8
Description		Rap guanine nucleotide exchange factor 5	integrin subunit beta 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions
Drugs
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	3 interacting genes: ITGAV TGFB1 VTN
Entrez ID		9771	3696
HPRD ID		15208	05001
Ensembl ID		ENSG00000136237	ENSG00000105855
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	P26012 Q9BUG9
PDB IDs		1WGY	6DJP 6OM1 6OM2 6UJA 6UJB 6UJC
Enriched GO Terms of Interacting Partners?
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