RASSF2 and STK3

Data Source:
BioGRID (two hybrid)

		RASSF2	STK3
Description		Ras association domain family member 2	serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Protein-containing Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Kinase Activity Protein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Skeletal System Development Ossification Protein Phosphorylation Cell Cycle Signal Transduction Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Via I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Bone Remodeling Homeostasis Of Number Of Cells Protein Stabilization Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		9 interacting genes: HRAS KDM1A KRAS PRMT3 PRMT6 RASSF5 S100Z STK3 SUV39H1	40 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MARK2 MBP MOB1B MOB3B MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 RASSF2 RASSF4 SAV1 SLMAP SNIP1 STK4 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		9770	6788
HPRD ID		15218	05433
Ensembl ID		ENSG00000101265	ENSG00000104375
Uniprot IDs		P50749	A0A087WZ06 A0A384MR07 Q13188
PDB IDs			3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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