RIPOR2 and RHOC

Data Source:
BioGRID (two hybrid)

		RIPOR2	RHOC
Description		RHO family interacting cell polarization regulator 2	ras homolog family member C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Apical Plasma Membrane Filopodium Stereocilium Stereocilium Membrane	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cleavage Furrow Stereocilium Cell Projection Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding 14-3-3 Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Chemotaxis Cell Adhesion Negative Regulation Of Cell Adhesion Sensory Perception Of Sound Negative Regulation Of Rho Protein Signal Transduction Establishment Of Protein Localization Positive Regulation Of Myoblast Differentiation Skeletal Muscle Fiber Development Protein Homooligomerization Positive Regulation Of Filopodium Assembly Auditory Receptor Cell Stereocilium Organization Cellular Response To Mechanical Stimulus Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Myoblast Fusion Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Cellular Response To Chemokine Regulation Of Establishment Of Cell Polarity Positive Regulation Of Neutrophil Extravasation Negative Regulation Of T Cell Migration Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity	Mitotic Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways			Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: MAP2K2 MTNR1B PER1 RHOA RHOC YWHAG	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		9750	389
HPRD ID		12881	01322
Ensembl ID		ENSG00000111913	ENSG00000155366
Uniprot IDs		A0A024QZY9 A0A024R028 A0A2R8Y7B3 A0A2R8YEE0 B7Z5J9 B7Z6D6 B7Z6U4 F5GX51 F5H029 Q9Y4F9	A0A024R0C8 P08134
PDB IDs			1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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