NOS1AP and SYN3

Data Source:
HPRD (in vivo)

		NOS1AP	SYN3
Description		nitric oxide synthase 1 adaptor protein	synapsin III
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Glutamatergic Synapse Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex	Synaptic Vesicle Postsynaptic Density Synaptic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Nitric-oxide Synthase Binding	ATP Binding
	Biological Process	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Synaptic Vesicle Clustering
Pathways			Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062061 20062063 25055868) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Long QT syndrome ( 32429735) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 23166209 30679814 20031603 29213071 16648850 24952745 22726844 19305408 19305409 19587794 29874175) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819) Alzheimer's disease progression score ( 29860282) Benign prostatic hyperplasia ( 30988330) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease ( 30804561) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549) Height ( 21998595 20881960 25282103 25429064 31562340) Interleukin-6 levels ( 22205395) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29617998 29785010 31959993 30054594) Metabolite levels ( 23823483) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 31170924) Trunk fat mass adjusted for trunk lean mass ( 32239398)
Interacting Genes		20 interacting genes: AKNAD1 APP CKM CT45A5 FAM133A FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4	7 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SYN1 SYN2
Entrez ID		9722	8224
HPRD ID		12023	04083
Ensembl ID		ENSG00000198929	ENSG00000185666
Uniprot IDs		O75052	A0A024R1I8 O14994 Q17R54 Q59EX7
PDB IDs			2P0A
Enriched GO Terms of Interacting Partners?
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