ECE2 and CASP10

Data Source:
BioGRID (two hybrid)

		ECE2	CASP10
Description		endothelin converting enzyme 2	caspase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Cell-cell Signaling Protein Processing Peptide Hormone Processing Methylation	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Peptide ligand-binding receptors	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Body mass index ( 29273807) Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)	Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		6 interacting genes: CASP10 CD53 CD86 MTNR1A SYNE4 UBC	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		9718	843
HPRD ID		09931	03458
Ensembl ID		ENSG00000145194	ENSG00000003400
Uniprot IDs		P0DPD6 P0DPD8	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs
Enriched GO Terms of Interacting Partners?
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